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Hello all,</div>
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I am currently running BUSTER v. 2026-04-2024 on an Apple M3 Pro Mac. I have encountered an error during refinement that I’ve never seen before. Refinement starts and appears to run normally, but after the first big cycle I get the following error:</div>
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<p style="direction: ltr; line-height: normal; margin: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);"> <b>ERROR</b> : [run_buster-0077] unable to combine</span></p>
<p style="line-height: normal; margin: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);"> ./01-BUSTER/Cycle-1/FRG.pdb.0 and</span></p>
<p style="line-height: normal; margin: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);"> ./01-BUSTER/Cycle-1/BUSTER.pdb - see</span></p>
<p style="line-height: normal; margin: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);"> ./01-BUSTER/Cycle-1/pdbcmb.log</span></p>
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<p style="line-height: normal; margin: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);"> <b>ERROR</b> : [refine-0058] problems in run_buster: see messages</span></p>
<p style="line-height: normal; margin: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);"> above</span></p>
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<p style="direction: ltr; margin-top: 0px; margin-bottom: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);">pdbcmb.log</span><span style="font-family: Aptos, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"> contains
the following:</span></p>
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<p style="direction: ltr; line-height: normal; margin: 0px;"><span style="font-family: Menlo; font-size: 10pt; color: rgb(0, 0, 0);">/Users/whitleymaj/GPhL/BUSTER_snapshot_20260424/autoBUSTER/bin/darwin/run_buster: line 2322: /Users/whitleymaj/GPhL/BUSTER_snapshot_20260424/autoBUSTER/bin/darwin/pdbcmb:
Permission denied</span></p>
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I have never had issues with permissions when using BUSTER before, although this is the first time I’ve used this particular release.</div>
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Any ideas as to how to overcome this?</div>
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Thanks,</div>
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Matthew</div>
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____________________________</div>
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<b>Matthew J. Whitley, Ph.D.</b> [c]</div>
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Scientist, RAS Structural Biology Group</div>
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Cancer Research Technology Program (CRTP)</div>
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Frederick National Laboratory for Cancer Research</div>
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National Institutes of Health</div>
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ATRF Room C1024</div>
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<a href="mailto:Matthew.Whitley@nih.gov" data-outlook-id="c352c731-920c-4fca-9de7-d3dcef05910f" style="color: rgb(70, 120, 134); margin-top: 0px; margin-bottom: 0px;"><u>Matthew.Whitley@nih.gov</u></a></div>
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