[sharp-discuss] SHARP with multiple SAD datasets and ignore isomorphous differences?

[Francis E Reyes]

Hi all

I'm curious about using multiple SAD datasets with poor isomorphism  
among them. I imagine I can specify multiple C-sites and multiple G- 
sites for each respective compound.

  However, how do I tell sharp to ignore the isomorphous differences?

Also, should scaling parameters be estimated/refined at all? I imagine  
that each compound will have its own Multiplier and isotropic scale  
factor.

Also, I imagine NANO_BGLO and NANO_CLOC should be refined as well?

Thanks!

F

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Francis E. Reyes M.Sc.
215 UCB
University of Colorado at Boulder