[buster-discuss] rhofit ??

Oliver Smart osmart at globalphasing.com
Wed Jun 29 19:08:46 CEST 2011

On Wed, 29 Jun 2011, Jonathan Grimes wrote:

>   Dear Buster Developers,
>    We have solved the structure of a viral polymerase bound
>    to viral adaptor protein.   We can see clear density for a peptide
>    10-15aa, so much smaller than the full length adaptor
>    protein.   We dont know if the rest of the adaptor protein is in crystal (and
>    is disordered) or had been cleaved.
>    We are also unclear of the peptide sequence at the moment (data to ~2.3A).
>    Is ligand fitting Rhofit appropriate to use ??  Ive never used Rhofit but have
>   only heard good stories.
>    Thanks
>    Jon


We have never tried rhofit on something this big. It handles cyclodextran 
but this sound like a case for normal coot type building?



| Dr Oliver Smart                             |
| Global Phasing Ltd., Cambridge UK           |
| http://www.globalphasing.com/people/osmart/ |

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