Hi Clemens and Pietro, With help from one of the people here, I have been get the SHARP GUI up and running. We already had Mozilla installed, that was good. The problem was fixed with the correct usage of "newuser" and "runSHARP". Thanks much, Raji Raji Edayathumangalam Dept. of Biochemistry & Molecular Biology Colorado State University Fort Collins, CO 80523 USA Tel:(970)491-4614 Fax:(970)491-0494